File:PegUricase.png

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DescriptionPegUricase.png	English: A comparison of uricase (pdb:1uox) and PEG-uricase (model). PEG-uricase includes 40 polymers of 10kDa PEG. PEGylation improves its solubility at physiological pH, increases serum half-life and reduces immunogenicity without compromising activity. Upper images show the whole tetramer, lower images show an example of one of the lysines that is PEGylated. (PEG-uricase model from reference^[1], only 36 PEG polymers included)
Date	22 February 2015
Source	Own work
Author	Evolution and evolvability

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↑ (3 January 2008). "PEG-uricase in the management of treatment-resistant gout and hyperuricemia.". Advanced drug delivery reviews 60 (1): 59-68. PMID 17826865.

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current	23:50, 21 February 2015		2,192 × 2,136 (1.65 MB)	Evolution and evolvability	User created page with UploadWizard

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